Carisoprodol alias soma tablets

Carisoprodol (trade name: Soma (USA)) is a centrally acting muscle relaxant whose active metabolite is meprobamate.
In neurogenic muscle spasms (cramps) and certain forms of arthritis, such as a paravertebral (next to the spine) muscle tension following a spinal degeneration.Carisoprodol relaxes the muscles. It relieves the pain of strains, sprains, spasms or other muscle injuries.
Carisoprodol is not a pain reliever. It should therefore not be used to treat general body aches.
Side effects and allergies

The intake of carisoprodol may cause stomach upset, cause heartburn, headache, dizziness or lightheadedness. Allergic reactions are very rare on Carisoprodol. The symptoms may be occurring rash, itching, swelling his, dizziness and difficulty breathing.
Carisoprodol is an allergic reaction at a possible acute urticaria (hives) and described a fixed drug eruption. [2]
Carisoprodol is excreted through breast milk. Nursing mothers should refrain from taking carisoprodol preparations.
Pharmacokinetics

Carisoprodol is taken up quite quickly by the body. The effect starts after about 30 minutes and lasts about two to six hours. It is metabolized by the liver via cytochrome P450 isoenzyme and CYP2C19. The half-life is approximately eight hours. It is excreted by the kidneys. A considerable proportion of carisoprodol is metabolized to meprobamate. The tranquilizer meprobamate is known for abuse and dependence. This explains the abuse potential of carisoprodol.
History [edit]

On 1 June 1959 gathered at Wayne State University in Detroit / Michigan several U.S. pharmacologists to discuss the newly developed drug Carisoprodol. Originally it was thought that carisoprodol has antiseptic, but then discovered the central muscle relaxant properties. [3] Carisoprodol was developed by Frank M. Berger at Wallace Laboratories. The development was based on meprobamate. [4] was the substitution of a hydrogen atom with an isopropyl group at one of the two carbamyl nitrogen atoms in a molecule of the intention to get with new pharmacological properties.
The trade name for the launch of carisoprodol soma 1959. The Greek word soma means body. The name Soma, however, is also the name of a fictional drug in Aldous Huxley's novel Brave New World of 1932. [5]
Literature

Bramness JG et al. Carisoprodol use and abuse in Norway. A pharmacoepidemiological study. In Br J Clin Pharmacol, 2 / 2007, p.210-8.
Fireplace I Shaskan D: Death due to massive overdose of meprobamate, in Am J Psychiatry, 115/1959, S.1123-4..
Hollister LE:. The pre-benzodiazepine era, in J Psychoactive Drugs, 15/1983, p.9-13.
Gaillard Y, et al. Meprobamate overdosage: a continuing problem. Sensitive GC-MS quantitation after solid phase extraction in 19 fatal cases. In Forensic Sci.Int, 86/1997, S.173-80.
Allen MD, et al. Meprobamate overdosage: a continuing problem, in Clin Toxicol, 11/1977, S.501-15.
Kintz P, et al:.. Fatal Meprobamate self-poisoning, Am J Forensic Med Pathol in, 9 / 1988, p.139-40.
Eeckhout E, et al. Meprobamate poisoning, hypotension and the Swan-Ganz catheter, Intensive Care Med, 14/1988, S.437-8..
Lhoste F et al. Treatment of hypotension in Meprobamate poisoning in N Engl J Med, 296/1977, S.1004.
Bedson H: Coma due to Meprobamate intoxication. Report of a case confirmed by chemical analysis., In Lancet, 273/1959, p.288-90.
Blumberg A, et al. Severe hypotension reactions following Meprobamate overdosage, in Ann Intern Med, 51/1959, S.607-12..
External links [edit]

↑ abcd sheet carisoprodol at Sigma-Aldrich, retrieved on 15 March, 2011.
↑ Fernandez-Rivas et al, urticaria to carisoprodol. In Allergy, 57/2002, p.55.
↑ Miller, JG, (editor), The pharmacology and clinical usefulness of carisoprodol, Detroit. Wayne State University, 1959.
↑ Berger F et al, The history, chemistry, and pharmacology of carisoprodol., In Annals of the New York Academy of Sciences, 86/1959, p.90-107.