Carisoprodol (trade name: Soma (USA)) is a centrally acting muscle relaxant whose active metabolite is meprobamate.
In neurogenic muscle spasms (cramps) and certain forms of arthritis, such as a paravertebral (next to the spine) muscle tension following a spinal degeneration.Carisoprodol relaxes the muscles. It relieves the pain of strains, sprains, spasms or other muscle injuries.
Carisoprodol is not a pain reliever. It should therefore not be used to treat general body aches.
Side effects and allergies
The intake of carisoprodol may cause stomach upset, cause heartburn, headache, dizziness or lightheadedness. Allergic reactions are very rare on Carisoprodol. The symptoms may be occurring rash, itching, swelling his, dizziness and difficulty breathing.
Carisoprodol is an allergic reaction at a possible acute urticaria (hives) and described a fixed drug eruption. [2]
Carisoprodol is excreted through breast milk. Nursing mothers should refrain from taking carisoprodol preparations.
Pharmacokinetics
Carisoprodol is taken up quite quickly by the body. The effect starts after about 30 minutes and lasts about two to six hours. It is metabolized by the liver via cytochrome P450 isoenzyme and CYP2C19. The half-life is approximately eight hours. It is excreted by the kidneys. A considerable proportion of carisoprodol is metabolized to meprobamate. The tranquilizer meprobamate is known for abuse and dependence. This explains the abuse potential of carisoprodol.
History [edit]
On 1 June 1959 gathered at Wayne State University in Detroit / Michigan several U.S. pharmacologists to discuss the newly developed drug Carisoprodol. Originally it was thought that carisoprodol has antiseptic, but then discovered the central muscle relaxant properties. [3] Carisoprodol was developed by Frank M. Berger at Wallace Laboratories. The development was based on meprobamate. [4] was the substitution of a hydrogen atom with an isopropyl group at one of the two carbamyl nitrogen atoms in a molecule of the intention to get with new pharmacological properties.
The trade name for the launch of carisoprodol soma 1959. The Greek word soma means body. The name Soma, however, is also the name of a fictional drug in Aldous Huxley's novel Brave New World of 1932. [5]
Literature
Bramness JG et al. Carisoprodol use and abuse in Norway. A pharmacoepidemiological study. In Br J Clin Pharmacol, 2 / 2007, p.210-8.
Fireplace I Shaskan D: Death due to massive overdose of meprobamate, in Am J Psychiatry, 115/1959, S.1123-4..
Hollister LE:. The pre-benzodiazepine era, in J Psychoactive Drugs, 15/1983, p.9-13.
Gaillard Y, et al. Meprobamate overdosage: a continuing problem. Sensitive GC-MS quantitation after solid phase extraction in 19 fatal cases. In Forensic Sci.Int, 86/1997, S.173-80.
Allen MD, et al. Meprobamate overdosage: a continuing problem, in Clin Toxicol, 11/1977, S.501-15.
Kintz P, et al:.. Fatal Meprobamate self-poisoning, Am J Forensic Med Pathol in, 9 / 1988, p.139-40.
Eeckhout E, et al. Meprobamate poisoning, hypotension and the Swan-Ganz catheter, Intensive Care Med, 14/1988, S.437-8..
Lhoste F et al. Treatment of hypotension in Meprobamate poisoning in N Engl J Med, 296/1977, S.1004.
Bedson H: Coma due to Meprobamate intoxication. Report of a case confirmed by chemical analysis., In Lancet, 273/1959, p.288-90.
Blumberg A, et al. Severe hypotension reactions following Meprobamate overdosage, in Ann Intern Med, 51/1959, S.607-12..
External links [edit]
↑ abcd sheet carisoprodol at Sigma-Aldrich, retrieved on 15 March, 2011.
↑ Fernandez-Rivas et al, urticaria to carisoprodol. In Allergy, 57/2002, p.55.
↑ Miller, JG, (editor), The pharmacology and clinical usefulness of carisoprodol, Detroit. Wayne State University, 1959.
↑ Berger F et al, The history, chemistry, and pharmacology of carisoprodol., In Annals of the New York Academy of Sciences, 86/1959, p.90-107.
Thursday 8 December 2011
Soma (R) 350mg tablets with Carisoprodol
Soma ® 350mg tablets
Active ingredient: Carisoprodol
How does the component?
Carisoprodol relaxes muscles and relieves pain and discomfort by strains, sprains, spasms or other muscle injuries. Muscle relaxers are for specific muscle injury and should not be used to treat general body aches.
Applications
Muscle relaxation
Warnings!
SOMA has a sedative effect and may impair the mental and / or physical abilities, is therefore of potentially hazardous tasks such as driving a motor vehicle or machinery discouraged.
The sedative effects of SOMA and other CNS depressants (eg alcohol, benzodiazepines, opiates, tricyclic antidepressants) may be mutually reinforcing. Therefore, special care should be exercised in patients concurrently taking more than one of these CNS depressants.
When the drug is not suitable for you (contraindications)?
Carisoprodol is contraindicated in patients with a history of acute porphyria or a hypersensitivity reaction to a carbamate such as meprobamate.
Pregnancy and lactation
Carisoprodol is excreted through breast milk. Nursing mothers should refrain from taking carisoprodol preparations.
Side effects
Listed are the major known side effects. They can occur, but need not, as each person responds differently to medications.
Sometimes people have allergic reactions to medications. If you have any signs of an allergic reaction, stop and call your doctor or pharmacist.
Stomach upsets
Heartburn
Headache
Dizziness
Dizziness
Allergic reactions (rare)
(Symptoms: rash, itching, swelling, dizziness and respiratory problems, acute urticaria (hives), fixed drug eruption)
Interactions
To the interaction of carisoprodol with other agents is limited experience.
CNS depressants
The calming effects of SOMA and other CNS depressants (eg alcohol, benzodiazepines, opiates, tricyclic antidepressants) may be enhanced. Therefore, caution is advised in patients taking more than one of these CNS depressants simultaneously. Concomitant use of SOMA and meprobamate, a metabolite of SOMA is not recommended.
CYP2C19 inhibitors and inducers
Carisoprodol is metabolized in the liver by CYP2C19 to meprobamate. The concomitant administration of CYP2C19 inhibitors such as omeprazole or fluvoxamine, with SOMA could result in an increased exposure of carisoprodol and meprobamate lower exposure. The concomitant administration of CYP2C19 inducers such as rifampicin or St John's wort with SOMA could result in decreased exposure of carisoprodol and increased exposure of meprobamate. Low dose aspirin also showed an effect on CYP2C19. The full pharmacological impact of these possible changes of requirements in terms of either efficacy or safety of SOMA is unknown.
This text makes no claim to completeness. It will only be clinically significant information. The description is neutral and based on the Federal Institute for Drugs and Medical Devices (BfArM) approved SPC. The information does not endorse or promote the drug They also do not replace the advice of a doctor or pharmacist.
Active ingredient: Carisoprodol
How does the component?
Carisoprodol relaxes muscles and relieves pain and discomfort by strains, sprains, spasms or other muscle injuries. Muscle relaxers are for specific muscle injury and should not be used to treat general body aches.
Applications
Muscle relaxation
Warnings!
SOMA has a sedative effect and may impair the mental and / or physical abilities, is therefore of potentially hazardous tasks such as driving a motor vehicle or machinery discouraged.
The sedative effects of SOMA and other CNS depressants (eg alcohol, benzodiazepines, opiates, tricyclic antidepressants) may be mutually reinforcing. Therefore, special care should be exercised in patients concurrently taking more than one of these CNS depressants.
When the drug is not suitable for you (contraindications)?
Carisoprodol is contraindicated in patients with a history of acute porphyria or a hypersensitivity reaction to a carbamate such as meprobamate.
Pregnancy and lactation
Carisoprodol is excreted through breast milk. Nursing mothers should refrain from taking carisoprodol preparations.
Side effects
Listed are the major known side effects. They can occur, but need not, as each person responds differently to medications.
Sometimes people have allergic reactions to medications. If you have any signs of an allergic reaction, stop and call your doctor or pharmacist.
Stomach upsets
Heartburn
Headache
Dizziness
Dizziness
Allergic reactions (rare)
(Symptoms: rash, itching, swelling, dizziness and respiratory problems, acute urticaria (hives), fixed drug eruption)
Interactions
To the interaction of carisoprodol with other agents is limited experience.
CNS depressants
The calming effects of SOMA and other CNS depressants (eg alcohol, benzodiazepines, opiates, tricyclic antidepressants) may be enhanced. Therefore, caution is advised in patients taking more than one of these CNS depressants simultaneously. Concomitant use of SOMA and meprobamate, a metabolite of SOMA is not recommended.
CYP2C19 inhibitors and inducers
Carisoprodol is metabolized in the liver by CYP2C19 to meprobamate. The concomitant administration of CYP2C19 inhibitors such as omeprazole or fluvoxamine, with SOMA could result in an increased exposure of carisoprodol and meprobamate lower exposure. The concomitant administration of CYP2C19 inducers such as rifampicin or St John's wort with SOMA could result in decreased exposure of carisoprodol and increased exposure of meprobamate. Low dose aspirin also showed an effect on CYP2C19. The full pharmacological impact of these possible changes of requirements in terms of either efficacy or safety of SOMA is unknown.
This text makes no claim to completeness. It will only be clinically significant information. The description is neutral and based on the Federal Institute for Drugs and Medical Devices (BfArM) approved SPC. The information does not endorse or promote the drug They also do not replace the advice of a doctor or pharmacist.
Michael Jackson lived in fear of death
Music legend Michael Jackson is reportedly feared in the months before his death for his life: the star was afraid someone would kill him in order to be closer to his property kommen.
Michael Jackson thought that someone would kill him to get his goods.
In the months before his death, Jacko was afraid that he seeks someone's life, to get his money or the publishing rights, which he owns. Jackson was not only the rights to his own songs, but also to more than 200 pieces of the Beatles, all in all they're worth an estimated € 700 million.
Brian Oxman, the attorney for the Jackson clan revealed: "Michael was afraid that someone would kill him, he was even afraid that someone would kill him to somehow come to the Beatles song.."
Oxman behauptetet further, some family members of the King of Pop believed that Jackson was put on drugs to be easily manipulated.
"He seemed to take a lot of strong narcotics, and many of these drugs were issued to its employees and wage earners," announces Oxman and accuses: "While people say about him, to have acted in his interest, they have used the drugs to control and manipulate him - and those things have ultimately killed him. "
Since his death from a suspected cardiac arrest is the struggle going on at Jackson's legacy. Oxman stressed that the family can monitor everything the police ". His family has asked the police in Los Angeles to investigate the case, a team that has already started to check his finances."
The first Jackson autopsy revealed no cause of death, but concluded a so-called 'Foul Play' from. Nevertheless, rumors say that the singer would have had nothing in his stomach, as a couple of half-digested tablets.
Supposedly the 'Thriller' a legend drug cocktail of painkillers, antidepressants and anti-anxiety, and have taken to relax the muscles, consisting of Vicodin, Dialudid, Xanax, Soma, Prilosec, Paxil, Zoloft, and Demerol.
The Jackson clan demanded a second autopsy, which should have delivered but also no more results.
Michael Jackson thought that someone would kill him to get his goods.
In the months before his death, Jacko was afraid that he seeks someone's life, to get his money or the publishing rights, which he owns. Jackson was not only the rights to his own songs, but also to more than 200 pieces of the Beatles, all in all they're worth an estimated € 700 million.
Brian Oxman, the attorney for the Jackson clan revealed: "Michael was afraid that someone would kill him, he was even afraid that someone would kill him to somehow come to the Beatles song.."
Oxman behauptetet further, some family members of the King of Pop believed that Jackson was put on drugs to be easily manipulated.
"He seemed to take a lot of strong narcotics, and many of these drugs were issued to its employees and wage earners," announces Oxman and accuses: "While people say about him, to have acted in his interest, they have used the drugs to control and manipulate him - and those things have ultimately killed him. "
Since his death from a suspected cardiac arrest is the struggle going on at Jackson's legacy. Oxman stressed that the family can monitor everything the police ". His family has asked the police in Los Angeles to investigate the case, a team that has already started to check his finances."
The first Jackson autopsy revealed no cause of death, but concluded a so-called 'Foul Play' from. Nevertheless, rumors say that the singer would have had nothing in his stomach, as a couple of half-digested tablets.
Supposedly the 'Thriller' a legend drug cocktail of painkillers, antidepressants and anti-anxiety, and have taken to relax the muscles, consisting of Vicodin, Dialudid, Xanax, Soma, Prilosec, Paxil, Zoloft, and Demerol.
The Jackson clan demanded a second autopsy, which should have delivered but also no more results.
Thursday 17 November 2011
information on soma tablets
Find information about soma tablets here soon. We are compiling the pharmaceutical facts.
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